Antigua was visited in 1493 by Christopher Columbus, who named it for the Church of Santa Maria de la Antigua in Sevilla, Spain. It was colonized by English settlers in 1632 and remained a British possession although it was raided by the French in 1666. The early colonizers were also attacked by Caribs, who were once one of the dominant peoples of the West Indies. At first tobacco was grown, but in the later 17th century sugar was found to be more profitable.

The nearby island of Barbuda was colonized in 1678. The crown granted the island to the Codrington family in 1685. It was planned as a slave-breeding colony but never became one; the slaves who were imported came to live self-reliantly in their own community.